MolNFT v1 · #148073 · protein
Human myelin protein P2 F57A mutant, monoclinic crystal form
6EW5 · Myelin P2 protein: “Human myelin protein P2 F57A mutant, monoclinic crystal form”. X-ray diffraction, 1 ligand (PLM), 7 pockets (best druggability 0.85). MolNFT v1 #148073 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6EW5
- Type
- protein
- Length
- 532 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myelin P2 protein
- UniProt
- P02689
- Ligands
- PLM
- Pockets
- 7 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 14% helix, 59% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Myelin P2 protein | protein | 133 | 14% helix, 59% strand | P02689 |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 357 | 0.85 | 0.94 | 35 | PLM |
| 2 | 334 | 0.84 | 0.94 | 35 | PLM |
| 3 | 758 | 0.83 | 0.86 | 67 | PLM |
| 4 | 1117 | 0.81 | 0.82 | 84 | PLM |
| 5 | 64 | 0.42 | 0.81 | 26 | empty |
Interfaces
5 interfaces between chains.
- C–D · 664 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 655 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 584 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 162 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 127 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02689
- Elsewhere: RCSB PDB 6EW5 · PDBe 6EW5 · UniProt P02689
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