MolNFT v1 · #148034 · protein
Crystal structure of antibody against schizophyllan
6EV1 · Heavy chain: “Crystal structure of antibody against schizophyllan”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #148034 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6EV1
- Type
- protein
- Length
- 2,536 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heavy chain; Light chain
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 9 distinct chains · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heavy chain | protein | 211 | 9% helix, 52% strand | — |
| B, D | Light chain | protein | 210 | 7% helix, 51% strand | — |
| C | Heavy chain | protein | 214 | 7% helix, 50% strand | — |
| E | Heavy chain | protein | 211 | 7% helix, 50% strand | — |
| F, J | Light chain | protein | 212 | 7% helix, 50% strand | — |
| G | Heavy chain | protein | 211 | 8% helix, 50% strand | — |
| H, L | Light chain | protein | 211 | 7% helix, 51% strand | — |
| I | Heavy chain | protein | 205 | 6% helix, 50% strand | — |
| K | Heavy chain | protein | 218 | 7% helix, 52% strand | — |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 889 | 0.75 | 0.79 | 83 | empty |
| 2 | 446 | 0.69 | 0.80 | 60 | empty |
| 3 | 480 | 0.69 | 0.80 | 56 | empty |
| 4 | 689 | 0.68 | 0.76 | 58 | empty |
| 5 | 516 | 0.67 | 0.78 | 52 | empty |
Interfaces
17 interfaces between chains.
- K–L · 1839 Ų buried · 15 hydrogen bonds · protein-protein
- G–H · 1753 Ų buried · 15 hydrogen bonds · protein-protein
- E–F · 1699 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 1680 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1679 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 24 disulfide (disulfide).
Compared structures
- 6EV1 · Crystal structure of antibody against schizophyllan · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6EV1 · PDBe 6EV1
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