MolNFT v1 · #148029 · protein
Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
6EUW · Polymerase basic protein 2: “Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an…”. X-ray diffraction, 1 ligand (BYB), 1 pocket (best druggability 0.53). MolNFT v1 #148029 on…
- PDB
- 6EUW
- Type
- protein
- Length
- 156 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase basic protein 2
- UniProt
- Q2LG68
- Ligands
- BYB
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 23% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase basic protein 2 | protein | 156 | 23% helix, 43% strand | Q2LG68 |
Ligands and binding sites
- BYB · (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid · ligand · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.53 | 0.80 | 20 | BYB |
Compared structures
- 6EUW · Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2LG68
- Elsewhere: RCSB PDB 6EUW · PDBe 6EUW · UniProt Q2LG68
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