MolNFT v1 · #148017 · protein

The GH43, beta 1,3 galactosidase, BT0265

6EUJ · Beta-glucanase: “The GH43, beta 1,3 galactosidase, BT0265”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #148017 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6EUJ
Type: protein
Length: 1,888 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-glucanase
UniProt: Q8AB46
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C, A, B, D	Beta-glucanase	protein	472	7% helix, 46% strand	Q8AB46

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1122	0.80	0.81	108	empty
2	1018	0.79	0.80	107	empty
3	311	0.73	0.85	37	empty
4	374	0.71	0.83	48	empty
5	293	0.70	0.84	30	empty

Interfaces

4 interfaces between chains.

A–D · 564 Å² buried · 5 hydrogen bonds · protein-protein
C–B · 547 Å² buried · 4 hydrogen bonds · protein-protein
B–D · 191 Å² buried · 2 hydrogen bonds · protein-protein
C–D · 99 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

6EUJ · The GH43, Beta 1,3 Galactosidase, BT0265 · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8AB46
Elsewhere: RCSB PDB 6EUJ · PDBe 6EUJ · UniProt Q8AB46

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