MolNFT v1 · #147951 · protein
Crystal structure of the legionella pneumoppila lapa
6ESL · Bacterial leucyl aminopeptidase: “Crystal structure of the legionella pneumoppila lapa”. X-ray diffraction, 1 ligand (ZN), 4 pockets (best druggability 0.77). MolNFT v1 #147951 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6ESL
- Type
- protein
- Length
- 719 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bacterial leucyl aminopeptidase
- EC
- 3.4.11.10
- UniProt
- A0A130VCV0
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bacterial leucyl aminopeptidase (EC 3.4.11.10) | protein | 359 | 40% helix, 19% strand | A0A130VCV0 |
| B | Bacterial leucyl aminopeptidase (EC 3.4.11.10) | protein | 360 | 40% helix, 19% strand | A0A130VCV0 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.77 | 0.95 | 29 | ZN |
| 2 | 163 | 0.77 | 0.93 | 32 | ZN |
| 3 | 371 | 0.64 | 0.79 | 42 | empty |
| 4 | 207 | 0.62 | 0.82 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 2818 Ų buried · 53 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6ESL · Crystal structure of the Legionella pneumoppila LapA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A130VCV0
- Elsewhere: RCSB PDB 6ESL · PDBe 6ESL · UniProt A0A130VCV0
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