MolNFT v1 · #147930 · protein
The crystal structure of mouse chloride intracellular channel protein 6
6ERZ: “The crystal structure of mouse chloride intracellular channel protein 6”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.72). MolNFT v1 #147930 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ERZ
- Type
- protein
- Length
- 450 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride intracellular channel protein 6
- UniProt
- Q8BHB9
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chloride intracellular channel protein 6 | protein | 223 | 48% helix, 10% strand | Q8BHB9 |
| B | Chloride intracellular channel protein 6 | protein | 227 | 48% helix, 9% strand | Q8BHB9 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 5 copies · chains A, B
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.72 | 0.94 | 18 | TRS |
| 2 | 212 | 0.48 | 0.75 | 29 | SO4 |
| 3 | 154 | 0.43 | 0.75 | 25 | empty |
| 4 | 137 | 0.39 | 0.73 | 23 | empty |
| 5 | 61 | 0.34 | 0.77 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 526 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6ERZ · The crystal structure of mouse chloride intracellular channel protein 6 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BHB9 · AlphaFold monomer V2.0 prediction for chloride intracellular channel protein 6 (Q8BHB9) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BHB9
- Elsewhere: RCSB PDB 6ERZ · PDBe 6ERZ · UniProt Q8BHB9
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