MolNFT v1 · #147818 · protein
DPP8 - apo, space group 20
6EOO · Dipeptidyl peptidase 8: “DPP8 - apo, space group 20”. X-ray diffraction, 20 pockets (best druggability 0.81). MolNFT v1 #147818 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6EOO
- Type
- protein
- Length
- 2,459 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dipeptidyl peptidase 8
- EC
- 3.4.14.5
- UniProt
- Q6V1X1
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dipeptidyl peptidase 8 (EC 3.4.14.5) | protein | 820 | 17% helix, 36% strand | Q6V1X1 |
| B | Dipeptidyl peptidase 8 (EC 3.4.14.5) | protein | 819 | 18% helix, 35% strand | Q6V1X1 |
| C | Dipeptidyl peptidase 8 (EC 3.4.14.5) | protein | 820 | 18% helix, 35% strand | Q6V1X1 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.81 | 0.98 | 33 | empty |
| 2 | 157 | 0.79 | 0.96 | 32 | empty |
| 3 | 1136 | 0.76 | 0.79 | 94 | empty |
| 4 | 984 | 0.76 | 0.79 | 92 | empty |
| 5 | 449 | 0.70 | 0.81 | 54 | empty |
Interfaces
2 interfaces between chains.
- A–C · 2312 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 393 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6V1X1
- Elsewhere: RCSB PDB 6EOO · PDBe 6EOO · UniProt Q6V1X1
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