MolNFT v1 · #147793 · protein
Crystal structure of mouse GADL1
6ENZ · Acidic amino acid decarboxylase GADL1: “Crystal structure of mouse GADL1”. X-ray diffraction; solution scattering, 1 ligand (PLP), 11 pockets (best druggability 0.80). MolNFT v1 #147793 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6ENZ
- Type
- protein
- Length
- 973 residues
- Chains
- 2
- Method
- x-ray diffraction; solution scattering
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acidic amino acid decarboxylase GADL1
- UniProt
- E9QP13
- Ligands
- PLP
- Pockets
- 11 · best druggability 0.80
Structure
x-ray diffraction; solution scattering · 2 distinct chains · 47% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acidic amino acid decarboxylase GADL1 | protein | 487 | 47% helix, 14% strand | E9QP13 |
| B | Acidic amino acid decarboxylase GADL1 | protein | 486 | 47% helix, 13% strand | E9QP13 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 629 | 0.80 | 0.86 | 57 | PLP |
| 2 | 680 | 0.79 | 0.84 | 60 | PLP |
| 3 | 195 | 0.57 | 0.80 | 24 | empty |
| 4 | 220 | 0.55 | 0.78 | 34 | empty |
| 5 | 173 | 0.55 | 0.80 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 7366 Ų buried · 92 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 6ENZ · Crystal structure of mouse GADL1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9QP13
- Elsewhere: RCSB PDB 6ENZ · PDBe 6ENZ · UniProt E9QP13
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