MolNFT v1 · #147761 · protein + DNA
Structure of the TN1549 transposon integrase (aa 82-397) in complex with circular intermediate DNA (CI5-DNA)
6EN0 · Int protein: “Structure of the TN1549 transposon integrase (aa 82-397) in complex with circular intermediate DNA (CI5-DNA)”. X-ray diffraction, 19 pockets (best druggability 0.68). MolNFT v1 #147761 on GenesisL1: 3D structure…
- PDB
- 6EN0
- Type
- protein + DNA
- Length
- 683 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Int protein; DNA (44-mer)
- UniProt
- Q7BP35
- Pockets
- 19 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 53% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Int protein | protein | 307 | 52% helix, 9% strand | Q7BP35 |
| C | DNA (44-mer) | dna | 36 | — | — |
| E | DNA (44-mer) | dna | 30 | — | — |
| B | Int protein | protein | 310 | 53% helix, 8% strand | Q7BP35 |
Pockets
19 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 413 | 0.68 | 0.81 | 33 | empty |
| 2 | 61 | 0.67 | 0.95 | 20 | empty |
| 3 | 177 | 0.65 | 0.86 | 29 | empty |
| 4 | 162 | 0.64 | 0.86 | 27 | empty |
| 5 | 405 | 0.62 | 0.77 | 54 | empty |
Interfaces
6 interfaces between chains.
- C–E · 1538 Ų buried · 122 hydrogen bonds · nucleic-nucleic
- E–B · 1208 Ų buried · 23 hydrogen bonds · protein-nucleic
- A–C · 1201 Ų buried · 17 hydrogen bonds · protein-nucleic
- A–E · 1154 Ų buried · 18 hydrogen bonds · protein-nucleic
- A–B · 1149 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 6EN0 · Structure of the Tn1549 transposon Integrase (aa 82-397) in complex with circular… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7BP35
- Elsewhere: RCSB PDB 6EN0 · PDBe 6EN0 · UniProt Q7BP35
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