MolNFT v1 · #147760 · protein + DNA
Structure of the TN1549 transposon integrase (aa 82-397, R225K) in complex with circular intermediate DNA (CI5-DNA)
6EMZ · Int protein: “Structure of the TN1549 transposon integrase (aa 82-397, R225K) in complex with circular intermediate DNA…”. X-ray diffraction, 14 pockets (best druggability 0.71). MolNFT v1 #147760 on GenesisL1: 3D structure, binding…
- PDB
- 6EMZ
- Type
- protein + DNA
- Length
- 703 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Int protein; DNA (44-mer)
- UniProt
- Q7BP35
- Pockets
- 14 · best druggability 0.71
Structure
x-ray diffraction · 3 distinct chains · 55% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Int protein | protein | 316 | 55% helix, 9% strand | Q7BP35 |
| C | DNA (44-mer) | dna | 36 | — | — |
| E | DNA (44-mer) | dna | 35 | — | — |
Pockets
14 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.71 | 0.87 | 34 | empty |
| 2 | 814 | 0.70 | 0.77 | 68 | empty |
| 3 | 244 | 0.69 | 0.86 | 33 | empty |
| 4 | 378 | 0.69 | 0.82 | 35 | empty |
| 5 | 581 | 0.67 | 0.77 | 74 | empty |
Interfaces
6 interfaces between chains.
- C–E · 1689 Ų buried · 122 hydrogen bonds · nucleic-nucleic
- A–B · 1427 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 1253 Ų buried · 18 hydrogen bonds · protein-nucleic
- E–B · 1241 Ų buried · 23 hydrogen bonds · protein-nucleic
- A–E · 1235 Ų buried · 24 hydrogen bonds · protein-nucleic
Compared structures
- 6EMZ · Structure of the Tn1549 transposon Integrase (aa 82-397, R225K) in complex with circular… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7BP35
- Elsewhere: RCSB PDB 6EMZ · PDBe 6EMZ · UniProt Q7BP35
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