MolNFT v1 · #14776 · protein
Structure of the N-wasp EVH1 domain-wip complex
1MKE · Fusion protein consisting of wiskott-aldrich syndrome…: “Structure of the N-wasp EVH1 domain-wip complex”. Solution nmr, 2 pockets (best druggability 0.58). MolNFT v1 #14776 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1MKE
- Type
- protein
- Length
- 144 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion protein consisting of wiskott-aldrich syndrome protein interacting protein (wip)…
- UniProt
- O43516, O08816
- Pockets
- 2 · best druggability 0.58
Structure
solution nmr · 1 distinct chain · 12% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion protein consisting of wiskott-aldrich syndrome protein interacting protein (wip), gsgsg linker, and neural wiskott- aldrich syndrome protein (N-wasp) | protein | 144 | 12% helix, 38% strand | O43516, O08816 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 280 | 0.58 | 0.78 | 30 | empty |
| 2 | 73 | 0.32 | 0.74 | 18 | empty |
Compared structures
- 1MKE · Structure of the N-WASP EVH1 Domain-WIP complex · the same entry in another collection · chain A against A, TM-score 1.00
- O08816 · AlphaFold monomer V2.0 prediction for neural wiskott-aldrich syndrome protein (O08816) · a predicted model of the same protein · chain A against A, TM-score 0.66
- O43516 · AlphaFold monomer V2.0 prediction for WAS/WASL-interacting protein family member 1… · a predicted model of the same protein · chain A against A, TM-score 0.14
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43516
- Every structure of UniProt O08816
- Elsewhere: RCSB PDB 1MKE · PDBe 1MKE · UniProt O43516 · UniProt O08816
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