MolNFT v1 · #147649 · protein
Structure of a glycosyltransferase
6EJK · Wlac protein: “Structure of a glycosyltransferase”. X-ray diffraction, 4 ligands (UDN, BUE, A2G), 7 pockets (best druggability 0.76). MolNFT v1 #147649 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6EJK
- Type
- protein
- Length
- 720 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Wlac protein
- UniProt
- O86151
- Ligands
- UDN, BUE, A2G, NDG
- Pockets
- 7 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Wlac protein | protein | 360 | 44% helix, 17% strand | O86151 |
Ligands and binding sites
- UDN · Uridine-Diphosphate-Methylene-N-acetyl-galactosamine · ligand · 2 copies · chains A, B
- BUE · NerylNeryl pyrophosphate · ligand · 2 copies · chains A, B
- A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · sugar · 4 copies · chains A, B
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 634 | 0.76 | 0.82 | 63 | A2G, UDN |
| 2 | 570 | 0.74 | 0.82 | 62 | A2G, UDN |
| 3 | 438 | 0.62 | 0.77 | 47 | empty |
| 4 | 142 | 0.44 | 0.75 | 16 | BUE |
| 5 | 138 | 0.43 | 0.75 | 15 | BUE |
Interfaces
1 interface between chains.
- A–B · 733 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 6EJK · Structure of a glycosyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O86151
- Elsewhere: RCSB PDB 6EJK · PDBe 6EJK · UniProt O86151
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.