MolNFT v1 · #147619 · protein

DYRK1A in complex with XMD14-124

6EIQ: “DYRK1A in complex with XMD14-124”. X-ray diffraction, 1 ligand (B6Z). MolNFT v1 #147619 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6EIQ
Type: protein
Length: 1,348 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q13627
Ligands: B6Z

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	342	—	Q13627
B	—	protein	340	—	Q13627
C	—	protein	333	—	Q13627
D	—	protein	333	—	Q13627

Ligands and binding sites

B6Z · [4-azanyl-2-[[2-methoxy-4-(4-methylpiperazin-1-yl) phenyl]amino]-1,3-thiazol-5-yl]-phenyl-methanone · ligand · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6EIQ · DYRK1A in complex with XMD14-124 · the same entry in another collection · chain D against D, TM-score 1.00
Q13627 · AlphaFold monomer V2.0 prediction for dual specificity tyrosine… · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13627
Elsewhere: RCSB PDB 6EIQ · PDBe 6EIQ · UniProt Q13627

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