MolNFT v1 · #147567 · protein

HA1.7 human T-cell receptor specific for influenza virus epitope pkyvkqntlklat presented by human leukocyte antigen HLA-DR0101

6EH9 · Human T cell receptor alpha chain: “HA1.7 human T-cell receptor specific for influenza virus epitope pkyvkqntlklat presented by human leukocyte…”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #147567 on…

PDB: 6EH9
Type: protein
Length: 443 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human T cell receptor alpha chain; Human T cell receptor beta chain
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Human T cell receptor alpha chain	protein	202	6% helix, 44% strand	—
B	Human T cell receptor beta chain	protein	241	5% helix, 52% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	887	0.74	0.78	76	empty
2	119	0.42	0.77	18	empty
3	66	0.41	0.80	22	empty
4	54	0.30	0.75	15	empty

Interfaces

1 interface between chains.

A–B · 2096 Å² buried · 24 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6EH9 · HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6EH9 · PDBe 6EH9

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