MolNFT v1 · #147566 · protein

HA1.7 human T-cell receptor specific for influenza virus epitope pkyvkqntlklat presented by human leukocyte antigen HLA-DR0101

6EH8 · Human T cell receptor alpha chain: “HA1.7 human T-cell receptor specific for influenza virus epitope pkyvkqntlklat presented by human leukocyte…”. X-ray diffraction, 4 pockets (best druggability 0.71). MolNFT v1 #147566 on…

PDB: 6EH8
Type: protein
Length: 442 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human T cell receptor alpha chain; Human T cell receptor beta chain
Pockets: 4 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Human T cell receptor alpha chain	protein	201	4% helix, 44% strand	—
B	Human T cell receptor beta chain	protein	241	7% helix, 51% strand	—

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1013	0.71	0.75	77	empty
2	134	0.45	0.77	24	empty
3	79	0.33	0.74	22	empty
4	55	0.30	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 2123 Å² buried · 24 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6EH8 · HA1.7 Human T-Cell Receptor specific for Influenza virus epitope PKYVKQNTLKLAT presented… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6EH8 · PDBe 6EH8

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