MolNFT v1 · #147565 · protein
F11 human T-cell receptor specific for influenza virus haaemagglutinin epitope pkyvkqntlklat carried by human leukocyte antigen HLA-DR0101
6EH7 · Human T cell receptor alpha chain: “F11 human T-cell receptor specific for influenza virus haaemagglutinin epitope pkyvkqntlklat carried by human…”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #147565 on…
- PDB
- 6EH7
- Type
- protein
- Length
- 442 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human T cell receptor alpha chain; Human T cell receptor beta chain
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human T cell receptor alpha chain | protein | 202 | 8% helix, 45% strand | — |
| B | Human T cell receptor beta chain | protein | 240 | 7% helix, 53% strand | — |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 12 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1160 | 0.73 | 0.77 | 82 | EDO, PEG |
| 2 | 126 | 0.41 | 0.76 | 21 | empty |
| 3 | 96 | 0.39 | 0.76 | 22 | EDO |
| 4 | 60 | 0.35 | 0.78 | 19 | EDO |
| 5 | 70 | 0.33 | 0.75 | 17 | EDO |
Interfaces
1 interface between chains.
- A–B · 2120 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 6EH7 · F11 Human T-Cell Receptor specific for influenza virus haaemagglutinin epitope… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6EH7 · PDBe 6EH7
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