MolNFT v1 · #147540 · protein
Crystal structure of the unphosphorylated IRAK4 kinase domain bound to a type I inhibitor
6EGD: “Crystal structure of the unphosphorylated IRAK4 kinase domain bound to a type I inhibitor”. X-ray diffraction, 1 ligand (J87). MolNFT v1 #147540 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6EGD
- Type
- protein
- Length
- 544 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9NWZ3
- Ligands
- J87
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D | — | protein | 276 | — | Q9NWZ3 |
| A | — | protein | 268 | — | Q9NWZ3 |
Ligands and binding sites
- J87 · N-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide · ligand · 2 copies · chains D, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6EGD · Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWZ3
- Elsewhere: RCSB PDB 6EGD · PDBe 6EGD · UniProt Q9NWZ3
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