MolNFT v1 · #147505 · protein

Crystal structure of mouse PP2A aalpha P179R mutant

6EF4 · SERINE/THREONINE-protein phosphatase 2A 65 kda regulatory…: “Crystal structure of mouse PP2A aalpha P179R mutant”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #147505 on GenesisL1: 3D structure, binding sites and…

PDB: 6EF4
Type: protein
Length: 572 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein phosphatase 2A 65 kda regulatory subunit a alpha isoform
UniProt: Q76MZ3
Pockets: 1 · best druggability 0.34

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein phosphatase 2A 65 kda regulatory subunit a alpha isoform	protein	572	70% helix, 0% strand	Q76MZ3

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.34	0.75	18	empty

Compared structures

6EF4 · Crystal structure of mouse PP2A Aalpha P179R mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q76MZ3 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A 65 kda… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q76MZ3
Elsewhere: RCSB PDB 6EF4 · PDBe 6EF4 · UniProt Q76MZ3

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