MolNFT v1 · #14748 · protein
Methionine repressor mutant (Q44K) complex with the corepressor SAM (S-adenosyl methionine) from escherichia COLI
1MJL · Methionine repressor protein metj: “Methionine repressor mutant (Q44K) complex with the corepressor SAM (S-adenosyl methionine) from escherichia…”. X-ray diffraction, 1 ligand (SAM), 1 pocket (best druggability 0.43). MolNFT v1…
- PDB
- 1MJL
- Type
- protein
- Length
- 208 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methionine repressor protein metj
- UniProt
- P0A8U6
- Ligands
- SAM
- Pockets
- 1 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Methionine repressor protein metj | protein | 104 | 44% helix, 13% strand | P0A8U6 |
Ligands and binding sites
- SAM · S-adenosylmethionine · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.43 | 0.81 | 15 | SAM |
Interfaces
1 interface between chains.
- A–B · 1799 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1MJL · Methionine repressor mutant (Q44K) complex with the corepressor SAM (S-adenosyl… · the same entry in another collection · chain B against B, TM-score 1.00
- P0A8U6 · AlphaFold monomer V2.0 prediction for met repressor (P0A8U6) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A8U6
- Elsewhere: RCSB PDB 1MJL · PDBe 1MJL · UniProt P0A8U6
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