MolNFT v1 · #147426 · protein
Hexamer-2-foldon HIV-1 capsid platform
6ECO · HIV-1 capsid platform protein: “Hexamer-2-foldon HIV-1 capsid platform”. X-ray diffraction, 4 pockets (best druggability 0.79). MolNFT v1 #147426 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6ECO
- Type
- protein
- Length
- 427 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HIV-1 capsid platform protein
- UniProt
- P04591
- Pockets
- 4 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 61% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HIV-1 capsid platform protein | protein | 210 | 62% helix, 2% strand | P04591 |
| D | HIV-1 capsid platform protein | protein | 217 | 60% helix, 3% strand | P04591 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 203 | 0.79 | 0.93 | 24 | empty |
| 2 | 920 | 0.74 | 0.78 | 108 | empty |
| 3 | 155 | 0.52 | 0.79 | 26 | empty |
| 4 | 76 | 0.32 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–D · 1088 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6ECO · Hexamer-2-Foldon HIV-1 capsid platform · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04591
- Elsewhere: RCSB PDB 6ECO · PDBe 6ECO · UniProt P04591
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