MolNFT v1 · #147373 · protein
Apo structure of the mitochondrial calcium uniporter protein MICU2
6EAZ · Calcium uptake protein 2, mitochondrial: “Apo structure of the mitochondrial calcium uniporter protein MICU2”. X-ray diffraction, 14 pockets (best druggability 0.61). MolNFT v1 #147373 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6EAZ
- Type
- protein
- Length
- 663 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium uptake protein 2, mitochondrial
- UniProt
- Q8CD10
- Pockets
- 14 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium uptake protein 2, mitochondrial | protein | 335 | 56% helix, 8% strand | Q8CD10 |
| B | Calcium uptake protein 2, mitochondrial | protein | 328 | 62% helix, 6% strand | Q8CD10 |
Ligands and binding sites
- GOL · Glycerol · additive · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.61 | 0.84 | 27 | GOL |
| 2 | 130 | 0.58 | 0.84 | 24 | GOL |
| 3 | 105 | 0.50 | 0.81 | 19 | GOL |
| 4 | 111 | 0.44 | 0.78 | 18 | GOL |
| 5 | 90 | 0.41 | 0.78 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1301 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6EAZ · Apo structure of the mitochondrial calcium uniporter protein MICU2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8CD10 · AlphaFold monomer V2.0 prediction for calcium uptake protein 2, mitochondrial (Q8CD10) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8CD10
- Elsewhere: RCSB PDB 6EAZ · PDBe 6EAZ · UniProt Q8CD10
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