MolNFT v1 · #147326 · protein
The crystal structure of bovine ultralong antibody bov-4
6E9I · Bovine ultralong antibody bov-4 heavy chain: “The crystal structure of bovine ultralong antibody bov-4”. X-ray diffraction, 20 pockets (best druggability 0.73). MolNFT v1 #147326 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6E9I
- Type
- protein
- Length
- 1,433 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bovine ultralong antibody bov-4 heavy chain; Bovine ultralong antibody bov-4 light chain
- UniProt
- Q3T101
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 6 distinct chains · 8% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bovine ultralong antibody bov-4 heavy chain | protein | 267 | 5% helix, 52% strand | — |
| B | Bovine ultralong antibody bov-4 light chain | protein | 215 | 8% helix, 52% strand | Q3T101 |
| C | Bovine ultralong antibody bov-4 heavy chain | protein | 259 | 8% helix, 54% strand | — |
| D | Bovine ultralong antibody bov-4 light chain | protein | 214 | 9% helix, 52% strand | Q3T101 |
| H | Bovine ultralong antibody bov-4 heavy chain | protein | 265 | 8% helix, 53% strand | — |
| L | Bovine ultralong antibody bov-4 light chain | protein | 213 | 8% helix, 54% strand | Q3T101 |
Pockets
20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 839 | 0.73 | 0.78 | 107 | empty |
| 2 | 662 | 0.68 | 0.77 | 58 | empty |
| 3 | 545 | 0.66 | 0.77 | 68 | empty |
| 4 | 202 | 0.53 | 0.78 | 33 | empty |
| 5 | 315 | 0.49 | 0.72 | 36 | empty |
Interfaces
10 interfaces between chains.
- A–B · 2122 Ų buried · 13 hydrogen bonds · protein-protein
- H–L · 2082 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 2044 Ų buried · 12 hydrogen bonds · protein-protein
- A–L · 457 Ų buried · 4 hydrogen bonds · protein-protein
- B–H · 377 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 27 disulfide (disulfide).
Compared structures
- 6E9I · The crystal structure of bovine ultralong antibody BOV-4 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3T101
- Elsewhere: RCSB PDB 6E9I · PDBe 6E9I · UniProt Q3T101
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