MolNFT v1 · #147315 · protein
Chimeric structure of saccharomyces cerevisiae GCN4 leucine zipper fused to staphylococcus aureus agrc cytoplasmic histidine kinase module (dataset isotropically truncated by HKL2000)
6E95 · Staphylococcus aureus agrc histidine kinase module fused to…: “Chimeric structure of saccharomyces cerevisiae GCN4 leucine zipper fused to staphylococcus aureus agrc…”. X-ray diffraction, 6 pockets (best druggability 0.67). MolNFT…
- PDB
- 6E95
- Type
- protein
- Length
- 469 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4…
- UniProt
- P03069, A0A224B0L3
- Pockets
- 6 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4 leucine zipper | protein | 240 | 59% helix, 16% strand | P03069, A0A224B0L3 |
| B | Staphylococcus aureus agrc histidine kinase module fused to saccharomyces cerevisiae GCN4 leucine zipper | protein | 229 | 59% helix, 17% strand | P03069, A0A224B0L3 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 510 | 0.67 | 0.78 | 39 | empty |
| 2 | 462 | 0.61 | 0.75 | 37 | empty |
| 3 | 179 | 0.44 | 0.74 | 24 | empty |
| 4 | 50 | 0.41 | 0.82 | 10 | empty |
| 5 | 81 | 0.34 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3329 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 6E95 · Chimeric structure of Saccharomyces cerevisiae GCN4 leucine zipper fused to… · the same entry in another collection · chain A against A, TM-score 1.00
- P03069 · AlphaFold monomer V2.0 prediction for general control transcription factor GCN4 (P03069) · a predicted model of the same protein · chain A against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03069
- Every structure of UniProt A0A224B0L3
- Elsewhere: RCSB PDB 6E95 · PDBe 6E95 · UniProt P03069 · UniProt A0A224B0L3
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