MolNFT v1 · #147305 · protein
The crystal structure of bovine ultralong antibody bov-1
6E8V · Bovine ultralong antibody bov-1 heavy chain: “The crystal structure of bovine ultralong antibody bov-1”. X-ray diffraction, 20 pockets (best druggability 0.84). MolNFT v1 #147305 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6E8V
- Type
- protein
- Length
- 3,566 residues
- Chains
- 16
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bovine ultralong antibody bov-1 heavy chain; Bovine ultralong antibody bov-1 light chain
- UniProt
- Q3T101
- Pockets
- 20 · best druggability 0.84
Structure
x-ray diffraction · 13 distinct chains · 4% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bovine ultralong antibody bov-1 heavy chain | protein | 214 | 1% helix, 53% strand | — |
| B | Bovine ultralong antibody bov-1 light chain | protein | 211 | 5% helix, 49% strand | Q3T101 |
| E | Bovine ultralong antibody bov-1 heavy chain | protein | 255 | 4% helix, 54% strand | — |
| F, K, d | Bovine ultralong antibody bov-1 light chain | protein | 215 | 6% helix, 47% strand | Q3T101 |
| H, U | Bovine ultralong antibody bov-1 heavy chain | protein | 255 | 2% helix, 54% strand | — |
| J | Bovine ultralong antibody bov-1 heavy chain | protein | 212 | 3% helix, 53% strand | — |
| L | Bovine ultralong antibody bov-1 light chain | protein | 214 | 6% helix, 50% strand | Q3T101 |
| O | Bovine ultralong antibody bov-1 heavy chain | protein | 211 | 1% helix, 51% strand | — |
| P | Bovine ultralong antibody bov-1 light chain | protein | 208 | 7% helix, 52% strand | Q3T101 |
| V | Bovine ultralong antibody bov-1 light chain | protein | 213 | 5% helix, 49% strand | Q3T101 |
| Y | Bovine ultralong antibody bov-1 heavy chain | protein | 213 | 4% helix, 53% strand | — |
| Z | Bovine ultralong antibody bov-1 light chain | protein | 206 | 5% helix, 44% strand | Q3T101 |
| c | Bovine ultralong antibody bov-1 heavy chain | protein | 254 | 4% helix, 54% strand | — |
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1055 | 0.84 | 0.85 | 116 | empty |
| 2 | 527 | 0.80 | 0.87 | 88 | empty |
| 3 | 672 | 0.80 | 0.84 | 102 | empty |
| 4 | 1020 | 0.77 | 0.79 | 114 | empty |
| 5 | 340 | 0.75 | 0.87 | 54 | empty |
Interfaces
39 interfaces between chains.
- E–F · 2200 Ų buried · 17 hydrogen bonds · protein-protein
- c–d · 2195 Ų buried · 20 hydrogen bonds · protein-protein
- H–L · 2099 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 2097 Ų buried · 16 hydrogen bonds · protein-protein
- O–P · 2088 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 49 disulfide (disulfide).
Compared structures
- 6E8V · The crystal structure of bovine ultralong antibody BOV-1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q3T101
- Elsewhere: RCSB PDB 6E8V · PDBe 6E8V · UniProt Q3T101
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