MolNFT v1 · #147214 · protein
Crystal structure of malaria transmission-blocking antibody 85RF45.1
6E64 · 85RF45.1 Fab heavy chain: “Crystal structure of malaria transmission-blocking antibody 85RF45.1”. X-ray diffraction, 13 pockets (best druggability 0.67). MolNFT v1 #147214 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6E64
- Type
- protein
- Length
- 858 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 85RF45.1 Fab heavy chain; 85RF45.1 Fab light chain
- Pockets
- 13 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | 85RF45.1 Fab heavy chain | protein | 217 | 6% helix, 55% strand | — |
| L, B | 85RF45.1 Fab light chain | protein | 213 | 7% helix, 50% strand | — |
| A | 85RF45.1 Fab heavy chain | protein | 215 | 11% helix, 53% strand | — |
Pockets
13 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 755 | 0.67 | 0.75 | 79 | empty |
| 2 | 346 | 0.55 | 0.74 | 39 | empty |
| 3 | 121 | 0.47 | 0.79 | 20 | empty |
| 4 | 55 | 0.39 | 0.81 | 18 | empty |
| 5 | 122 | 0.35 | 0.72 | 23 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1984 Ų buried · 15 hydrogen bonds · protein-protein
- H–L · 1937 Ų buried · 15 hydrogen bonds · protein-protein
- L–B · 289 Ų buried · 2 hydrogen bonds · protein-protein
- H–B · 12 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6E64 · Crystal structure of malaria transmission-blocking antibody 85RF45.1 · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6E64 · PDBe 6E64
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.