MolNFT v1 · #147036 · protein
Mitochondrial peroxiredoxin from leishmania infantum in complex with unfolding client protein after heat stress
6E0F · Mitochondrial 2-cys-peroxiredoxin: “Mitochondrial peroxiredoxin from leishmania infantum in complex with unfolding client protein after heat…”. Electron microscopy, 20 pockets (best druggability 0.70). MolNFT v1 #147036 on…
- PDB
- 6E0F
- Type
- protein
- Length
- 1,740 residues
- Chains
- 10
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial 2-cys-peroxiredoxin
- EC
- 1.11.1.-
- UniProt
- Q95U89
- Pockets
- 20 · best druggability 0.70
Structure
electron microscopy · 1 distinct chain · 22% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| J, A, I, E, G, F, B, C, D, H | Mitochondrial 2-cys-peroxiredoxin (EC 1.11.1.-) | protein | 174 | 22% helix, 24% strand | Q95U89 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 526 | 0.70 | 0.80 | 61 | empty |
| 2 | 425 | 0.69 | 0.81 | 46 | empty |
| 3 | 426 | 0.69 | 0.81 | 49 | empty |
| 4 | 433 | 0.69 | 0.80 | 46 | empty |
| 5 | 440 | 0.68 | 0.80 | 47 | empty |
Interfaces
10 interfaces between chains.
- D–H · 1390 Ų buried · 23 hydrogen bonds · protein-protein
- F–B · 1387 Ų buried · 23 hydrogen bonds · protein-protein
- G–C · 1381 Ų buried · 23 hydrogen bonds · protein-protein
- J–A · 1367 Ų buried · 24 hydrogen bonds · protein-protein
- I–E · 1331 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 6E0F · Mitochondrial peroxiredoxin from Leishmania infantum in complex with unfolding client… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q95U89
- Elsewhere: RCSB PDB 6E0F · PDBe 6E0F · UniProt Q95U89
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