MolNFT v1 · #14700 · protein

Solution structure of murine macrophage inflammatory protein-2, NMR, 20 structures

1MI2: “Solution structure of murine macrophage inflammatory protein-2, NMR, 20 structures”. Solution nmr, 3 pockets (best druggability 0.70). MolNFT v1 #14700 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MI2
Type: protein
Length: 146 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrophage inflammatory protein-2
UniProt: P10889
Pockets: 3 · best druggability 0.70

Structure

solution nmr · 1 distinct chain · 15% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Macrophage inflammatory protein-2	protein	73	15% helix, 23% strand	P10889

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.70	0.95	22	empty
2	90	0.43	0.79	19	empty
3	81	0.42	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 797 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1MI2 · Solution structure of murine macrophage inflammatory protein-2, NMR, 20 structures · the same entry in another collection · chain A against A, TM-score 1.00
P10889 · AlphaFold monomer V2.0 prediction for C-X-C motif chemokine 2 (P10889) · a predicted model of the same protein · chain B against A, TM-score 0.60

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10889
Elsewhere: RCSB PDB 1MI2 · PDBe 1MI2 · UniProt P10889

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