MolNFT v1 · #1470 · protein

Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody

1B2W · Protein (antibody (light chain)): “Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon…”. X-ray diffraction, 5 pockets (best druggability 0.53). MolNFT v1 #1470 on GenesisL1…

PDB: 1B2W
Type: protein
Length: 434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (antibody (light chain)); Protein (antibody (heavy chain))
Pockets: 5 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 4% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Protein (antibody (light chain))	protein	214	2% helix, 49% strand	—
H	Protein (antibody (heavy chain))	protein	220	7% helix, 38% strand	—

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	176	0.53	0.79	25	empty
2	114	0.44	0.77	26	empty
3	170	0.42	0.73	34	empty
4	82	0.35	0.75	20	empty
5	52	0.24	0.72	17	empty

Interfaces

1 interface between chains.

L–H · 1862 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide, 1 modified (disulfide, cyclization).

Compared structures

1B2W · Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1B2W · PDBe 1B2W

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