MolNFT v1 · #146929 · protein
Crystal structure of chalcone synthase from pinus sylvestris
6DXA: “Crystal structure of chalcone synthase from pinus sylvestris”. X-ray diffraction, 8 pockets (best druggability 0.71). MolNFT v1 #146929 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6DXA
- Type
- protein
- Length
- 783 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chalcone synthase
- EC
- 2.3.1.74
- UniProt
- P30079
- Pockets
- 8 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chalcone synthase (EC 2.3.1.74) | protein | 391 | 43% helix, 23% strand | P30079 |
| B | Chalcone synthase (EC 2.3.1.74) | protein | 392 | 44% helix, 22% strand | P30079 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 375 | 0.71 | 0.83 | 44 | empty |
| 2 | 299 | 0.69 | 0.83 | 40 | empty |
| 3 | 54 | 0.68 | 0.97 | 16 | empty |
| 4 | 119 | 0.45 | 0.78 | 20 | empty |
| 5 | 72 | 0.41 | 0.79 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 3184 Ų buried · 69 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30079
- Elsewhere: RCSB PDB 6DXA · PDBe 6DXA · UniProt P30079
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