MolNFT v1 · #146918 · protein
Crystal structure of semet phased viral otu domain protease from qalyub virus
6DWX · RNA-dependent RNA polymerase: “Crystal structure of semet phased viral otu domain protease from qalyub virus”. X-ray diffraction, 9 pockets (best druggability 0.66). MolNFT v1 #146918 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6DWX
- Type
- protein
- Length
- 458 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-dependent RNA polymerase
- UniProt
- A0A191KWB3
- Pockets
- 9 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | RNA-dependent RNA polymerase | protein | 151 | 43% helix, 29% strand | A0A191KWB3 |
| B | RNA-dependent RNA polymerase | protein | 156 | 41% helix, 28% strand | A0A191KWB3 |
Pockets
9 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 153 | 0.66 | 0.87 | 34 | empty |
| 2 | 58 | 0.33 | 0.76 | 13 | empty |
| 3 | 62 | 0.33 | 0.76 | 15 | empty |
| 4 | 58 | 0.33 | 0.77 | 14 | empty |
| 5 | 55 | 0.32 | 0.76 | 11 | empty |
Interfaces
3 interfaces between chains.
- A–C · 423 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 416 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 396 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 modified (engineered).
Compared structures
- 6DWX · Crystal structure of SeMet phased viral OTU domain protease from Qalyub virus · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A191KWB3
- Elsewhere: RCSB PDB 6DWX · PDBe 6DWX · UniProt A0A191KWB3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.