MolNFT v1 · #14691 · protein

Model of neurospora crassa proton ATPase

1MHS · Plasma membrane ATPase: “Model of neurospora crassa proton ATPase”. Electron crystallography, 20 pockets (best druggability 0.88). MolNFT v1 #14691 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1MHS
Type: protein
Length: 1,840 residues
Chains: 2
Method: electron crystallography
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasma membrane ATPase
EC: 3.6.3.6
UniProt: P07038
Pockets: 20 · best druggability 0.88

Structure

electron crystallography · 1 distinct chain · 45% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Plasma membrane ATPase (EC 3.6.3.6)	protein	920	45% helix, 9% strand	P07038

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1099	0.88	0.89	148	empty
2	464	0.82	0.89	69	empty
3	1088	0.79	0.80	107	empty
4	1092	0.78	0.80	108	empty
5	328	0.77	0.88	48	empty

Interfaces

1 interface between chains.

A–B · 876 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1MHS · Model of Neurospora crassa proton ATPase · the same entry in another collection · chain A against A, TM-score 1.00
P07038 · AlphaFold monomer V2.0 prediction for plasma membrane ATPase (P07038) · a predicted model of the same protein · chain A against A, TM-score 0.67

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07038
Elsewhere: RCSB PDB 1MHS · PDBe 1MHS · UniProt P07038

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.