MolNFT v1 · #146792 · protein

Re-refinement of P. falciparum orotidine 5'-monophosphate decarboxylase

6DSQ: “Re-refinement of P. falciparum orotidine 5'-monophosphate decarboxylase”. X-ray diffraction, 7 pockets (best druggability 0.61). MolNFT v1 #146792 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DSQ
Type: protein
Length: 618 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Orotidine 5'-monophosphate decarboxylase
EC: 4.1.1.23
UniProt: Q8T6J6
Pockets: 7 · best druggability 0.61

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Orotidine 5'-monophosphate decarboxylase (EC 4.1.1.23)	protein	309	55% helix, 16% strand	Q8T6J6
B	Orotidine 5'-monophosphate decarboxylase (EC 4.1.1.23)	protein	309	54% helix, 15% strand	Q8T6J6

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	315	0.61	0.79	44	empty
2	279	0.61	0.79	42	empty
3	62	0.38	0.79	12	empty
4	101	0.37	0.74	15	empty
5	70	0.37	0.78	18	empty

Interfaces

1 interface between chains.

A–B · 2275 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

6DSQ · Re-refinement of P. falciparum orotidine 5'-monophosphate decarboxylase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8T6J6
Elsewhere: RCSB PDB 6DSQ · PDBe 6DSQ · UniProt Q8T6J6

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