MolNFT v1 · #146772 · protein
Dihydrofolate reductase (DHFR) of aspergillus flavus in complex with a small molecule inhibitor
6DRS: “Dihydrofolate reductase (DHFR) of aspergillus flavus in complex with a small molecule inhibitor”. X-ray diffraction, 3 ligands (H8A, NAP, SO4). MolNFT v1 #146772 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6DRS
- Type
- protein
- Length
- 244 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- B8NBN5
- Ligands
- H8A, NAP, SO4
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 244 | — | B8NBN5 |
Ligands and binding sites
- H8A · 3-{[(3R)-7,9-diamino-3-methyl-2,3-dihydrofuro[2,3-f]quinazolin-4-yl]oxy}benzonitrile · ligand · chains A
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- SO4 · Sulfate ion · ion · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6DRS · Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B8NBN5
- Elsewhere: RCSB PDB 6DRS · PDBe 6DRS · UniProt B8NBN5
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