MolNFT v1 · #14663 · protein
Crystal structure of O6-methylguanine-DNA methyltransferase from hyperthermophilic archaeon pyrococcus kodakaraensis strain KOD1
1MGT · Protein (O6-methylguanine-DNA methyltransferase): “Crystal structure of O6-methylguanine-DNA methyltransferase from hyperthermophilic archaeon pyrococcus…”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.50).…
- PDB
- 1MGT
- Type
- protein
- Length
- 169 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (O6-methylguanine-DNA methyltransferase)
- EC
- 2.1.1.63
- UniProt
- O74023
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (O6-methylguanine-DNA methyltransferase) (EC 2.1.1.63) | protein | 169 | 44% helix, 19% strand | O74023 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 114 | 0.50 | 0.81 | 16 | empty |
Compared structures
- 1MGT · Crystal structure of O6-methylguanine-DNA methyltransferase from hyperthermophilic… · the same entry in another collection · chain A against A, TM-score 1.00
- O74023 · AlphaFold monomer V2.0 prediction for methylated-DNA--protein- cysteine methyltransferase… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O74023
- Elsewhere: RCSB PDB 1MGT · PDBe 1MGT · UniProt O74023
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