MolNFT v1 · #14662 · protein

The solution structure of melanoma growth stimulating activity

1MGS · Human melanoma growth stimulatory activity: “The solution structure of melanoma growth stimulating activity”. Solution nmr, 2 pockets (best druggability 0.30). MolNFT v1 #14662 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1MGS
Type: protein
Length: 146 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Human melanoma growth stimulatory activity
UniProt: P09341
Pockets: 2 · best druggability 0.30

Structure

solution nmr · 1 distinct chain · 18% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Human melanoma growth stimulatory activity	protein	73	18% helix, 25% strand	P09341

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	80	0.30	0.73	20	empty
2	57	0.28	0.74	19	empty

Interfaces

1 interface between chains.

A–B · 917 Å² buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1MGS · The solution structure of melanoma growth stimulating activity · the same entry in another collection · chain A against A, TM-score 1.00
P09341 · AlphaFold monomer V2.0 prediction for growth-regulated alpha protein (P09341) · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09341
Elsewhere: RCSB PDB 1MGS · PDBe 1MGS · UniProt P09341

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