MolNFT v1 · #146611 · protein

De novo design of a protein heterodimer with specificity mediated by hydrogen bond networks

6DMP · Designed orthogonal protein DHD13_XAAA_A: “De novo design of a protein heterodimer with specificity mediated by hydrogen bond networks”. Solution nmr, 1 pocket (best druggability 0.30). MolNFT v1 #146611 on GenesisL1: 3D structure…

PDB: 6DMP
Type: protein
Length: 159 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Designed orthogonal protein DHD13_XAAA_A; Designed orthogonal protein DHD13_XAAA_B
Pockets: 1 · best druggability 0.30

Structure

solution nmr · 2 distinct chains · 86% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Designed orthogonal protein DHD13_XAAA_A	protein	77	90% helix, 0% strand	—
B	Designed orthogonal protein DHD13_XAAA_B	protein	82	82% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.30	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 1682 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6DMP · De Novo Design of a Protein Heterodimer with Specificity Mediated by Hydrogen Bond… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6DMP · PDBe 6DMP

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