MolNFT v1 · #146562 · protein

Crystal structures of an influenza a hemagglutinin antibody Fab CH65:7969D2

6DLA · CH65:7969D2 Fab heavy chain: “Crystal structures of an influenza a hemagglutinin antibody Fab CH65:7969D2”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.56). MolNFT v1 #146562 on GenesisL1: 3D structure, binding…

PDB: 6DLA
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CH65:7969D2 Fab heavy chain; CH65:7969D2 Fab light chain
Ligands: SO4
Pockets: 4 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	CH65:7969D2 Fab heavy chain	protein	226	8% helix, 50% strand	—
L	CH65:7969D2 Fab light chain	protein	210	8% helix, 50% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · chains L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	396	0.56	0.74	50	empty
2	77	0.40	0.79	18	empty
3	83	0.32	0.73	17	empty
4	56	0.28	0.74	16	empty

Interfaces

1 interface between chains.

H–L · 1915 Å² buried · 24 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6DLA · Crystal structures of an influenza A hemagglutinin antibody Fab CH65:7969d2 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6DLA · PDBe 6DLA

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