MolNFT v1 · #146419 · protein

Igabasnfr fluorescent GABA sensor precursor

6DGV: “Igabasnfr fluorescent GABA sensor precursor”. X-ray diffraction, 1 ligand (CRO), 4 pockets (best druggability 0.72). MolNFT v1 #146419 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DGV
Type: protein
Length: 553 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fluorescent GABA sensor precursor
Ligands: CRO
Pockets: 4 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fluorescent GABA sensor precursor	protein	553	30% helix, 33% strand	—

Ligands and binding sites

CRO · {2-[(1R,2R)-1-amino-2-hydroxypropyl]-4-(4-hydroxybenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl}acetic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	209	0.72	0.88	37	CRO
2	182	0.57	0.80	30	empty
3	178	0.51	0.78	28	empty
4	210	0.49	0.75	34	empty

Modifications

Observed in the structure: 2 cofactor (chromophore).

Compared structures

6DGV · iGABASnFR Fluorescent GABA Sensor precursor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6DGV · PDBe 6DGV

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