MolNFT v1 · #146375 · protein
Crystal structure of the 11S subunit of the plasmodium falciparum proteasome, PA28
6DFK · Subunit of proteaseome activator COMPLEX,PUTATIVE: “Crystal structure of the 11S subunit of the plasmodium falciparum proteasome, PA28”. X-ray diffraction, 1 ligand (SO4), 20 pockets (best druggability 0.87). MolNFT v1 #146375 on…
- PDB
- 6DFK
- Type
- protein
- Length
- 3,125 residues
- Chains
- 14
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Subunit of proteaseome activator COMPLEX,PUTATIVE
- UniProt
- Q8I374
- Ligands
- SO4
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 14 distinct chains · 68% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 216 | 70% helix, 1% strand | Q8I374 |
| B | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 232 | 66% helix, 4% strand | Q8I374 |
| C | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 222 | 68% helix, 3% strand | Q8I374 |
| D | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 233 | 65% helix, 4% strand | Q8I374 |
| E | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 212 | 72% helix, 1% strand | Q8I374 |
| F | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 229 | 66% helix, 4% strand | Q8I374 |
| G | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 213 | 71% helix, 1% strand | Q8I374 |
| H | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 216 | 70% helix, 3% strand | Q8I374 |
| I | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 236 | 64% helix, 4% strand | Q8I374 |
| J | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 214 | 71% helix, 1% strand | Q8I374 |
| K | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 223 | 71% helix, 2% strand | Q8I374 |
| L | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 233 | 64% helix, 4% strand | Q8I374 |
| M | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 213 | 71% helix, 1% strand | Q8I374 |
| N | Subunit of proteaseome activator COMPLEX,PUTATIVE | protein | 233 | 65% helix, 4% strand | Q8I374 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 60 copies · chains A, G, B, C, D, E, F, H, I, J, K, L, M, N
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 650 | 0.87 | 0.92 | 93 | empty |
| 2 | 507 | 0.81 | 0.87 | 63 | empty |
| 3 | 620 | 0.74 | 0.80 | 75 | SO4 |
| 4 | 652 | 0.74 | 0.80 | 71 | SO4 |
| 5 | 669 | 0.74 | 0.80 | 72 | SO4 |
Interfaces
27 interfaces between chains.
- H–I · 3304 Ų buried · 35 hydrogen bonds · protein-protein
- K–L · 3198 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 3142 Ų buried · 27 hydrogen bonds · protein-protein
- M–N · 3110 Ų buried · 29 hydrogen bonds · protein-protein
- A–B · 2978 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 6DFK · Crystal structure of the 11S subunit of the Plasmodium falciparum proteasome, PA28 · the same entry in another collection · chain M against M, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8I374
- Elsewhere: RCSB PDB 6DFK · PDBe 6DFK · UniProt Q8I374
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