MolNFT v1 · #146355 · protein

Anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with sulfate

6DF0 · 4G10-4D5 antibody light chain: “Anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with sulfate”. X-ray diffraction, 1 ligand (SO4), 2 pockets (best druggability 0.59). MolNFT v1 #146355 on GenesisL1: 3D structure, binding sites…

PDB: 6DF0
Type: protein
Length: 422 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 4G10-4D5 antibody light chain; 4G10-4D5 antibody heavy chain
Ligands: SO4
Pockets: 2 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	4G10-4D5 antibody light chain	protein	211	7% helix, 53% strand	—
H	4G10-4D5 antibody heavy chain	protein	211	7% helix, 52% strand	—

Ligands and binding sites

SO4 · Sulfate ion · ion · chains L, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	492	0.59	0.73	49	empty
2	87	0.36	0.75	19	empty

Interfaces

1 interface between chains.

L–H · 1724 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6DF0 · anti-phosphotyrosine antibody 4G10-4D5 Fab complexed with sulfate · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6DF0 · PDBe 6DF0

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