MolNFT v1 · #146280 · protein

Crystal structure of human anti-tau antibody cbtau-27.1 Fab in complex with a human tau peptide

6DCW · Light chain of CBTAU27.1 Fab: “Crystal structure of human anti-tau antibody cbtau-27.1 Fab in complex with a human tau peptide”. X-ray diffraction, 2 pockets (best druggability 0.61). MolNFT v1 #146280 on GenesisL1: 3D structure…

PDB: 6DCW
Type: protein
Length: 451 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Light chain of CBTAU27.1 Fab; Heavy chain of CBTAU27.1 Fab; Tau peptide
Pockets: 2 · best druggability 0.61

Structure

x-ray diffraction · 3 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Light chain of CBTAU27.1 Fab	protein	219	5% helix, 53% strand	—
H	Heavy chain of CBTAU27.1 Fab	protein	223	8% helix, 53% strand	—
T	Tau peptide	protein	9	0% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	536	0.61	0.74	63	empty
2	181	0.48	0.76	25	empty

Interfaces

3 interfaces between chains.

L–H · 2014 Å² buried · 14 hydrogen bonds · protein-protein
H–T · 429 Å² buried · 6 hydrogen bonds · protein-protein
L–T · 236 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6DCW · Crystal structure of human anti-tau antibody CBTAU-27.1 Fab in complex with a human tau… · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6DCW · PDBe 6DCW

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