MolNFT v1 · #146279 · protein

Crystal structure of human anti-tau antibody cbtau-27.1

6DCV · Light chain of CBTAU27.1 Fab: “Crystal structure of human anti-tau antibody cbtau-27.1”. X-ray diffraction, 7 pockets (best druggability 0.62). MolNFT v1 #146279 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DCV
Type: protein
Length: 892 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Light chain of CBTAU27.1 Fab; Heavy chain of cbtau-27.1 Fab
Pockets: 7 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L, A	Light chain of CBTAU27.1 Fab	protein	220	6% helix, 52% strand	—
H, B	Heavy chain of cbtau-27.1 Fab	protein	226	9% helix, 52% strand	—

Ligands and binding sites

GOL · Glycerol · additive · 3 copies · chains L, H, A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	547	0.62	0.75	64	empty
2	550	0.61	0.74	65	empty
3	502	0.61	0.75	52	empty
4	255	0.56	0.78	29	empty
5	51	0.56	0.91	19	GOL

Interfaces

4 interfaces between chains.

A–B · 2129 Å² buried · 17 hydrogen bonds · protein-protein
L–H · 2096 Å² buried · 18 hydrogen bonds · protein-protein
H–A · 180 Å² buried · 4 hydrogen bonds · protein-protein
H–B · 85 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 10 disulfide (disulfide).

Compared structures

6DCV · Crystal structure of human anti-tau antibody CBTAU-27.1 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6DCV · PDBe 6DCV

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