MolNFT v1 · #146256 · protein

Rsv-neutralizing human antibody AM22

6DC4 · Fab AM22 heavy chain: “Rsv-neutralizing human antibody AM22”. X-ray diffraction, 4 pockets (best druggability 0.60). MolNFT v1 #146256 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DC4
Type: protein
Length: 437 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab AM22 heavy chain; Fab AM22 light chain
UniProt: Q6GMX6, Q8TCD0
Pockets: 4 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Fab AM22 heavy chain	protein	222	7% helix, 52% strand	Q6GMX6
L	Fab AM22 light chain	protein	215	7% helix, 53% strand	Q8TCD0

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 17 copies · chains H, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	475	0.60	0.75	49	EDO
2	200	0.46	0.74	32	EDO
3	68	0.45	0.82	23	EDO
4	94	0.35	0.74	17	empty

Interfaces

1 interface between chains.

H–L · 1859 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

6DC4 · RSV-neutralizing human antibody AM22 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6GMX6
Every structure of UniProt Q8TCD0
Elsewhere: RCSB PDB 6DC4 · PDBe 6DC4 · UniProt Q6GMX6 · UniProt Q8TCD0

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