MolNFT v1 · #146241 · protein

RNA-recognition motif 1 of human MSI2

6DBP · RNA-binding protein musashi homolog 2: “RNA-recognition motif 1 of human MSI2”. X-ray diffraction, 2 pockets (best druggability 0.37). MolNFT v1 #146241 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DBP
Type: protein
Length: 166 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-binding protein musashi homolog 2
UniProt: Q96DH6
Pockets: 2 · best druggability 0.37

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-binding protein musashi homolog 2	protein	84	24% helix, 42% strand	Q96DH6
B	RNA-binding protein musashi homolog 2	protein	82	24% helix, 40% strand	Q96DH6

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.37	0.79	12	empty
2	94	0.36	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 1117 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6DBP · RNA-recognition motif 1 of human MSI2 · the same entry in another collection · chain A against A, TM-score 1.00
Q96DH6 · AlphaFold monomer V2.0 prediction for RNA-binding protein musashi homolog 2 (Q96DH6) · a predicted model of the same protein · chain B against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96DH6
Elsewhere: RCSB PDB 6DBP · PDBe 6DBP · UniProt Q96DH6

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