MolNFT v1 · #146106 · protein

Crystal structure of an inactivate variant of the quorum-sensing master regulator hapr from protease-deficient non-O1, non-O139 vibrio cholerae strain V2

6D7R · HEMAGGLUTININ/PROTEASE regulatory protein: “Crystal structure of an inactivate variant of the quorum-sensing master regulator hapr from…”. X-ray diffraction, 4 pockets (best druggability 0.74). MolNFT v1 #146106 on GenesisL1: 3D…

PDB: 6D7R
Type: protein
Length: 394 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HEMAGGLUTININ/PROTEASE regulatory protein
UniProt: B2CKP3
Pockets: 4 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	HEMAGGLUTININ/PROTEASE regulatory protein	protein	197	72% helix, 1% strand	B2CKP3

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	303	0.74	0.86	40	empty
2	560	0.71	0.80	51	empty
3	257	0.69	0.84	26	empty
4	55	0.28	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 1446 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6D7R · Crystal structure of an inactivate variant of the quorum-sensing master regulator HapR… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B2CKP3
Elsewhere: RCSB PDB 6D7R · PDBe 6D7R · UniProt B2CKP3

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