MolNFT v1 · #145976 · protein
Thermostablilized dephosphorylated chicken cftr
6D3R · Cystic fibrosis transmembrane conductance regulator: “Thermostablilized dephosphorylated chicken cftr”. Electron microscopy, 1 ligand (ATP), 20 pockets (best druggability 0.81). MolNFT v1 #145976 on GenesisL1: 3D structure, binding…
- PDB
- 6D3R
- Type
- protein
- Length
- 1,127 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cystic fibrosis transmembrane conductance regulator
- EC
- 3.6.3.49
- Ligands
- ATP
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 64% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cystic fibrosis transmembrane conductance regulator (EC 3.6.3.49) | protein | 1127 | 64% helix, 11% strand | — |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 955 | 0.81 | 0.82 | 85 | empty |
| 2 | 736 | 0.77 | 0.82 | 75 | empty |
| 3 | 1004 | 0.76 | 0.78 | 100 | empty |
| 4 | 248 | 0.70 | 0.85 | 41 | empty |
| 5 | 200 | 0.70 | 0.87 | 34 | empty |
Compared structures
- 6D3R · Thermostablilized dephosphorylated chicken CFTR · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6D3R · PDBe 6D3R
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.