MolNFT v1 · #145683 · protein
Mycobacterium marinum cytochrome P450 CYP124A1 in the substrate-free form
6CVC · Cytochrome P450 124A1, CYP124A1: “Mycobacterium marinum cytochrome P450 CYP124A1 in the substrate-free form”. X-ray diffraction, 2 ligands (HEM, SO4), 2 pockets (best druggability 0.86). MolNFT v1 #145683 on GenesisL1: 3D structure…
- PDB
- 6CVC
- Type
- protein
- Length
- 422 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome P450 124A1, CYP124A1
- UniProt
- B2HHT9
- Ligands
- HEM, SO4
- Pockets
- 2 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytochrome P450 124A1, CYP124A1 | protein | 422 | 51% helix, 11% strand | B2HHT9 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · chains A
- SO4 · Sulfate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1169 | 0.86 | 0.87 | 106 | HEM |
| 2 | 119 | 0.72 | 0.93 | 26 | empty |
Compared structures
- 6CVC · Mycobacterium marinum cytochrome P450 CYP124A1 in the substrate-free form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B2HHT9
- Elsewhere: RCSB PDB 6CVC · PDBe 6CVC · UniProt B2HHT9
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