MolNFT v1 · #145676 · protein
Cryoem structure of human enterovirus D68 full particle (after incubation with low molecular weight heparin)
6CV5 · Viral protein 1: “Cryoem structure of human enterovirus D68 full particle (after incubation with low molecular weight heparin)”. Electron microscopy, 12 pockets (best druggability 0.67). MolNFT v1 #145676 on GenesisL1: 3D structure…
- PDB
- 6CV5
- Type
- protein
- Length
- 804 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Viral protein 1; Viral protein 3; Viral protein 2; Viral protein 4
- UniProt
- A0A0X7Z9B1, E9RIT6, A0A097ZN88, A0A0P0DH17
- Pockets
- 12 · best druggability 0.67
Structure
electron microscopy · 4 distinct chains · 10% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Viral protein 1 | protein | 290 | 8% helix, 32% strand | A0A0X7Z9B1 |
| B | Viral protein 3 | protein | 247 | 7% helix, 30% strand | E9RIT6 |
| C | Viral protein 2 | protein | 237 | 13% helix, 37% strand | A0A097ZN88 |
| D | Viral protein 4 | protein | 30 | 23% helix, 10% strand | A0A0P0DH17 |
Pockets
12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.67 | 0.85 | 34 | empty |
| 2 | 222 | 0.52 | 0.76 | 34 | empty |
| 3 | 158 | 0.50 | 0.78 | 27 | empty |
| 4 | 131 | 0.47 | 0.78 | 25 | empty |
| 5 | 151 | 0.46 | 0.77 | 27 | empty |
Interfaces
6 interfaces between chains.
- A–B · 4807 Ų buried · 71 hydrogen bonds · protein-protein
- A–C · 2114 Ų buried · 43 hydrogen bonds · protein-protein
- B–C · 1840 Ų buried · 23 hydrogen bonds · protein-protein
- A–D · 932 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 833 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 6CV5 · CryoEM structure of human enterovirus D68 full particle (after incubation with low… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0X7Z9B1
- Every structure of UniProt E9RIT6
- Every structure of UniProt A0A097ZN88
- Every structure of UniProt A0A0P0DH17
- Elsewhere: RCSB PDB 6CV5 · PDBe 6CV5 · UniProt A0A0X7Z9B1 · UniProt E9RIT6 · UniProt A0A097ZN88 · UniProt A0A0P0DH17
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