MolNFT v1 · #145675 · protein
Cryoem structure of human enterovirus D68 emptied particle (after incubation with low molecular weight heparin)
6CV4 · Viral protein 1: “Cryoem structure of human enterovirus D68 emptied particle (after incubation with low molecular weight…”. Electron microscopy, 7 pockets (best druggability 0.69). MolNFT v1 #145675 on GenesisL1: 3D structure…
- PDB
- 6CV4
- Type
- protein
- Length
- 659 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Viral protein 1; Viral protein 3; Viral protein 2
- UniProt
- A0A0X7Z9B1, E9RIT6, A0A097ZN88
- Pockets
- 7 · best druggability 0.69
Structure
electron microscopy · 3 distinct chains · 10% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Viral protein 1 | protein | 225 | 8% helix, 40% strand | A0A0X7Z9B1 |
| B | Viral protein 3 | protein | 234 | 9% helix, 32% strand | E9RIT6 |
| C | Viral protein 2 | protein | 200 | 14% helix, 38% strand | A0A097ZN88 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 239 | 0.69 | 0.85 | 27 | empty |
| 2 | 96 | 0.40 | 0.77 | 18 | empty |
| 3 | 73 | 0.37 | 0.77 | 18 | empty |
| 4 | 88 | 0.37 | 0.76 | 16 | empty |
| 5 | 103 | 0.37 | 0.74 | 19 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3394 Ų buried · 54 hydrogen bonds · protein-protein
- A–C · 1867 Ų buried · 38 hydrogen bonds · protein-protein
- B–C · 1753 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 6CV4 · CryoEM structure of human enterovirus D68 emptied particle (after incubation with low… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0X7Z9B1
- Every structure of UniProt E9RIT6
- Every structure of UniProt A0A097ZN88
- Elsewhere: RCSB PDB 6CV4 · PDBe 6CV4 · UniProt A0A0X7Z9B1 · UniProt E9RIT6 · UniProt A0A097ZN88
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