MolNFT v1 · #145583 · protein

V308E mutant of cytochrome P450 2D6 complexed with prinomastat

6CSD: “V308E mutant of cytochrome P450 2D6 complexed with prinomastat”. X-ray diffraction, 4 ligands (HEM, PN0, CPS). MolNFT v1 #145583 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6CSD
Type: protein
Length: 916 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P10635
Ligands: HEM, PN0, CPS, ZN

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	462	—	P10635
B	—	protein	454	—	P10635

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
PN0 · Prinomastat · ligand · 2 copies · chains A, B
CPS · 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate · ligand · 2 copies · chains A, B
ZN · Zinc ion · metal · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6CSD · V308E mutant of cytochrome P450 2D6 complexed with prinomastat · the same entry in another collection · chain A against A, TM-score 1.00
P10635 · AlphaFold monomer V2.0 prediction for cytochrome P450 2D6 (P10635) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10635
Elsewhere: RCSB PDB 6CSD · PDBe 6CSD · UniProt P10635

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